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Welcome to fufezan.net


Fields that I am interested in


Python, Javascript, d3.js and zsh.

Mass Spectrometry

Extracting high quality data using Python.

Protein Structures

Screening structure for patterns and simulating dynamics


Making data intuitively understandable while maintaining the elegance.


Former licensed PADI instructor


Roasting and brewing coffee since 2010.


Scientific career starting 1994 until now

  • 2017 -

    Cellzome / GSK

    Head of Computational Mass Spectrometry at Cellzome GmbH - R&D Platform Technology & Science GSK, Heidelberg

  • 2008 - 2016

    University of Muenster

    From Alexander von Humboldt fellow to Habilitation

  • 2006 - 2008

    City College of New York

    Structural bioinformatics with focus on continuum electrostatics with Prof. Dr. M. Gunner at the Physics Department, City College of New York. Supervisor

  • 2002 - 2005


    Institute of Plant Biochemistry, University Freiburg &
 Biophysics department, CEA Saclay, Paris with Drs. A. Krieger-Liszkay and A. W. Rutherford

  • 1997 - 2001

    Diploma Biochemistry

    At the University of Freiburg

  • 1994 - 1997


    Zwischenprüfung in Mathematics and Chemistry at the University of Freiburg


Scientific publications in peer reviewed journals










μ(coffee) d-1



N-Glycoproteomic characterization of mannosidase and xylosyltransferase mutant strains of chlamydomonas reinhardtii

35. Schulze S., Oltmanns A., Machnik N., Liu G., Xu N., Jarmatz N., Scholz M., Sugimoto K., Fufezan C., Huang K. and Hippler M.

Plant Physiology 2018, 176 pp
pyQms enables universal and accurate quantification of mass spectrometry data

34. Leufken Johannes, Niehues Anna, Sarin L. Peter, Wessel Florian, Hippler Michael, Leidel Sebastian A. and Fufezan Christian

Molecular & Cellular Proteomics 2017, 16 pp 1736-1745
Identification of methylated GnTI-dependent N-glycans in Botryococcus brauni

33. Schulze Stefan, Urzica Eugen, Reijnders Maarten J.M.F., van de Geest Henri, Warris Sven, Bakker Linda V., Fufezan Christian, Martins dos Santos Vitor A.P., Schaap Peter J., Peters Sander A. and Hippler Michael

New Phytologist 2017, 215 pp 1361-1369
Comparative transcriptome and proteome analysis reveals a global impact of the nitrogen regulators AreA and AreB on secondary metabolism in Fusarium fujikuroi

32. Pfannmüller Andreas, Leufken Johannes, Studt Lena, Michielse Caroline B., Sieber Christian M. K., Güldener Ulrich, Hawat Susan, Hippler Michael, Fufezan Christian and Tudzynski Bettina

PLOS ONE 2017, 12 pp e0176194 [link]
Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition

31. Beck Florian, Geiger Jörg, Gambaryan Stepan, Solari Fiorella A., Dell'aica Margherita, Loroch Stefan, Mattheij Nadine J., Mindukshev Igor, Pötz Oliver, Jurk Kerstin, Burkhart Julia M., Fufezan Christian, Heemskerk Johan W.M., Walter Ulrich, Zahedi Ren'e P. and Sickmann Albert

Blood 2017, 129 pp e1-e12
Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition

30. Beck Florian, Solari Fiorella A., Dell'aica Margherita, Loroch Stefan, Burkhart Julia M., Zahedi Ren'e P., Sickmann Albert, Geiger Jörg, Gambaryan Stepan, Mindukshev Igor, Mattheij Nadine J., Heemskerk Johan W. M., Pötz Oliver, Jurk Kerstin, Walter Ulrich and Fufezan Christian

Blood 2017, 129 pp e1-e12
Phosphorylation of GENOMES UNCOUPLED 4 Alters Stimulation of Mg Chelatase Activity in Angiosperms

29. Richter Andreas Sven, Hochheuser Caroline, Fufezan Christian, Heinze Laura, Kuhnert Franziska and Grimm Bernhard

Plant Physiology 2016, 172 pp 1578-1595 [link]
Ten Simple Rules for Taking Advantage of git and GitHub Rule 1 . Use GitHub to track your projects

28. Perez-riverol Yasset, Gatto Laurent, Wang Rui, Sachsenberg Timo, Katz Daniel S, Pollard Tom J, Konovalov Alexander and Flight Robert M

PLOS Computational Biology 2016, accepted pp 048744 [link]
Ursgal Universal Python Module Combining Common Bottom-Up Proteomics Tools for Large-Scale Analysis

27. Kremer Lukas P.M., Leufken Johannes, Oyunchimeg Purevdulam, Schulze Stefan and Fufezan Christian

Journal of Proteome Research 2016, 15 pp 788-794 [link]
Calredoxin represents a novel type of calcium-dependent sensor-responder connected to redox regulation in the chloroplast

26. Karina Hochmal Ana, Zinzius Karen, Charoenwattanasatien Ratana, Gäbelein Philipp, Mutoh Risa, Tanaka Hideaki, Schulze Stefan, Liu Gai, Scholz Martin, Nordhues Andre, Offenborn Jan Niklas, Petroutsos Dimitris, Finazzi Giovanni, Fufezan Christian, Huang Kaiyao, Kurisu Genji and Hippler Michael

Nature Communications 2016, 7 pp
STATE TRANSITION7-Dependent Phosphorylation Is Modulated by Changing Environmental Conditions and Its Absence Triggers Remodeling of Photosynthetic Protein Complexes

25. Bergner Sonja Verena, Scholz Martin, Trompelt Kerstin, Barth Johannes, Gäbelein Philipp, Steinbeck Janina, Xue Huidan, Clowez Sophie, Fucile Geoffrey, Goldschmidt-Clermont Michel, Fufezan Christian and Hippler Michael

Plant Physiology 2015, 168 pp 615-634 [link]
An evolutionary approach uncovers a diverse response of tRNA 2-thiolation to elevated temperatures in yeast

24. Alings Fiona, Sarin L Peter, Fufezan Christian, Drexler Hannes C A and Leidel Sebastian A

RNA 2015, 21 pp 202-212 [link]
The Vac14-interaction Network Is Linked to Regulators of the Endolysosomal and Autophagic Pathway.

23. Schulze Ulf, Vollenbröker Beate, Braun Daniela A, Van Le Truc, Granado Daniel, Kremerskothen Joachim, Fränzel Benjamin, Klosowski Rafael, Barth Johannes, Fufezan Christian, Wolters Dirk A, Pavenstädt Hermann and Weide Thomas

Molecular & cellular proteomics : MCP 2014, 13 pp 1397-411 [link]
Proton Gradient Regulation5-Like1-Mediated Cyclic Electron Flow Is Crucial for Acclimation to Anoxia and Complementary to Nonphotochemical Quenching in Stress Adaptation

22. Kukuczka Bernadeta, Magneschi Leonardo, Petroutsos Dimitris, Steinbeck Janina, Bald Till, Powikrowska Marta, Fufezan Christian, Finazzi Giovanni and Hippler Michael

Plant Physiology 2014, 165 pp 1604-1617 [link]
pyGCluster a novel hierarchical clustering approach.

21. Jaeger Daniel, Barth Johannes, Niehues Anna and Fufezan Christian

Bioinformatics (Oxford England) 2014, 30 pp 896-8 [link]
The interplay of light and oxygen in the reactive oxygen stress response of Chlamydomonas reinhardtii dissected by quantitative mass spectrometry.

20. Barth Johannes, Bergner Sonja Verena, Jaeger Daniel, Niehues Anna, Schulze Stefan, Scholz Martin and Fufezan Christian

Molecular & cellular proteomics : MCP 2014, 13 pp 969-89 [link]
Exploring the N-glycosylation pathway in Chlamydomonas reinhardtii unravels novel complex structures.

19. Mathieu-Rivet Elodie, Scholz Martin, Arias Carolina, Dardelle Flavien, Schulze Stefan, Le Mauff Franccois, Teo Gavin, Hochmal Ana Karina, Blanco-Rivero Amaya, Loutelier-Bourhis Corinne, Kiefer-Meyer Marie-Christine, Fufezan Christian, Burel Carole, Lerouge Patrice, Martinez Flor, Bardor Muriel and Hippler Michael

Molecular & cellular proteomics : MCP 2013, 12 pp 3160-83 [link]
The Metabolic Status Drives Acclimation of Iron Deficiency Responses in Chlamydomonas reinhardtii as Revealed by Proteomics Based Hierarchical Clustering and Reverse Genetics.

18. Höhner Ricarda, Barth Johannes, Magneschi Leonardo, Jaeger Daniel, Niehues Anna, Bald Till, Grossman Arthur, Fufezan Christian and Hippler Michael

Molecular & cellular proteomics : MCP 2013, 12 pp 2774-90 [link]
Calcium-dependent regulation of cyclic photosynthetic electron transfer by a CAS ANR1 and PGRL1 complex.

17. Terashima Mia, Petroutsos Dimitris, Hüdig Meike, Tolstygina Irina, Trompelt Kerstin, Gäbelein Philipp, Fufezan Christian, Kudla Jörg, Weinl Stefan, Finazzi Giovanni and Hippler Michael

Proceedings of the National Academy of Sciences of the United States of America 2012, 109 pp 17717-22 [link]
Residues PsaB-Asp612 and PsaB-Glu613 of photosystem I confer pH dependent binding of plastocyanin and cytochrome c6

16. Kuhlgert Sebastian, Drepper Friedel, Fufezan Christian, Sommer Frederik and Hippler Michael

Biochemistry 2012, 51 pp 7297-7303 [link]
Identification of key residues for pH dependent activation of violaxanthin de-epoxidase from Arabidopsis thaliana

15. Fufezan Christian, Simionato Diana and Morosinotto Tomas

PLoS ONE 2012, 7 pp
pymzML--Python module for high-throughput bioinformatics on mass spectrometry data.

14. Bald Till, Barth Johannes, Niehues Anna, Specht Michael, Hippler Michael and Fufezan Christian

Bioinformatics (Oxford England) 2012, 28 pp 1052-3 [link]
Proteomics to go: Proteomatic enables the user-friendly creation of versatile MS/MS data evaluation workflows.

13. Specht Michael, Kuhlgert Sebastian, Fufezan Christian and Hippler Michael

Bioinformatics (Oxford England) 2011, 27 pp 1183-4 [link]
Mutation analysis of violaxanthin de-epoxidase identifies substrate-binding sites and residues involved in catalysis.

12. Saga Giorgia, Giorgetti Alejandro, Fufezan Christian, Giacometti Giorgio M, Bassi Roberto and Morosinotto Tomas

The Journal of Biological Chemistry 2010, 285 pp 23763-70 [link]
The role of Buergi-Dunitz interactions in the structural stability of proteins.

11. Fufezan Christian

Proteins 2010, 78 pp 2831-8 [link]
Geometric constraints for porphyrin binding in helical protein binding sites.

10. Negron Christopher, Fufezan Christian and Koder Ronald L

Proteins: Structure Function and Bioinformatics 2009, 74 pp 400-16 [link]
p3d--Python module for structural bioinformatics.

9. Fufezan Christian and Specht Michael

BMC bioinformatics 2009, 10 pp 258 [link]
Singlet oxygen production in photosystem II and related protection mechanism.

8. Krieger-Liszkay Anja, Fufezan Christian and Trebst Achim

Photosynthesis research 2008, 98 pp 551-64 [link]
Ligand preference and orientation in b- and c-type heme-binding proteins.

7. Fufezan Christian, Zhang Jun and Gunner M R

Proteins: Structure Function and Bioinformatics 2008, 73 pp 690-704 [link]
Influence of the Redox Potential of the Primary Quinone Electron Acceptor on Photoinhibition in Photosystem II

6. Fufezan Christian, Gross CM, Sjödin Martin, Rutherford A William, Krieger-Liszkay Anja and Kirilovsky Diana

The Journal of Biological Chemistry 2007, 282 pp 12492-12502 [link]
Herbicide-induced changes in charge recombination and redox potential of QtextlessinftextgreaterAtextless/inftextgreater in the T4 mutant of Blastochloris viridis

5. Fufezan C., Drepper F., Juhnke H.D., Lancaster C.R.D., Un S., Rutherford A.W. and Krieger-Liszkay A.

Biochemistry 2005, 44 pp
Herbicide-Induced Changes in Charge Recombination and Redox Potential of Q A in the T4 Mutant of Blastochloris Viridis

4. Fufezan Christian, Drepper Friedel, Juhnke HD, Lancaster C.Roy D., Un Sun, Rutherford A William and Krieger-Liszkay Anja

Biochemistry 2005, pp 5931-5939 [link]
Secondary quinone in photosystem II of Thermosynechococcus elongatus: semiquinone-iron EPR signals and temperature dependence of electron transfer.

3. Fufezan Christian, Zhang Chunxi, Krieger-Liszkay Anja and Rutherford A William

Biochemistry 2005, 44 pp 12780-9 [link]
Recombinant water-soluble chlorophyll protein from Brassica oleracea var. Botrys binds various chlorophyll derivatives.

2. Schmidt Kristin, Fufezan Christian, Krieger-Liszkay Anja, Satoh Hiroyuki and Paulsen Harald

Biochemistry 2003, 42 pp 7427-33 [link]
Singlet oxygen production in herbicide-treated photosystem II.

1. Fufezan Christian, Rutherford a William and Krieger-Liszkay Anja

FEBS letters 2002, 532 pp 407-10 [link]

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